HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributyltin Chloride → HCID 19879218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributyltin Chloride | HCID 15096 | — |
| Reactant | 5H-Pyrrolo[1,2-a]imidazole, 2-(4-fluorophenyl)-6,7-dihydro- | HCID 10569630 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19879218 | HCID 19879218 | — |
Reaction Conditions
| Temperature | -30 °C |
|---|
Reaction Steps
To a -78° C. solution of 2-(4-fluorophenyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a]imidazole (2.0 g, 0.010 mole) in 60 ml of tetrahydrofuran (THF) is added 4.0 ml of 2.5M n-butyllithium. The solution is warmed to -30° C. for 20 minutes and then tributyltin chloride (3.3 g, 0.01 mole) in THF is added. The reaction is allowed to warm gradually to 20° C. and then is quenched with saturated ammonium chloride. Further workup and purification on silica as described in Example 6b yields the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05145858 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-5dd3b3fc74764756879e59c5ed6e657c |
| Source note | uspto-grants-1992_09 |