Phosphorus pentachloride → 88708-72-9

HRID 1885745Notes

Reaction equation

[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=O)[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:17]>>[F:10][C:9]([F:12])([F:11])[C:8]([Cl:17])=[N:7][CH2:6][C:5]1[CH:14]=[CH:15][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 24819Phosphorus pentachloride

HCID 580806Acetamide, N-[(4-chlorophenyl)methyl]-2,2,2-trifluoro-

Product 1

HCID 1098886688708-72-9Yield 61.5%

Procedure

A mixture N-(p-chlorobenzyl)-2,2,2-trifluoroacetamide (100.0 g, 0.421 mol) and phosphorus pentachloride (87.7 g, 0.421 mol) is heated to 100° C., stirred for two hours and vacuum distilled to obtain the title product as a clear colorless liquid (66.3 g, bp 110°-112° C./7.5 mm Hg).

Workup

distillationvacuum distilled

Sources & evidence

ORD record: ord-e2e4e739949640e5a857ed4741792eba
Source dataset: uspto-grants-1992_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05145986

Reaction notes

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