6-Methoxy-2-naphthylacetic acid → HCID 10988208, compound

HRID 1885751Notes

Reaction equation

HRID 1885751 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][C:14]([OH:16])=O)[CH:7]=[CH:6]2.C(Cl)(=O)C([Cl:20])=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][C:14]([Cl:20])=[O:16])[CH:7]=[CH:6]2

Participants

3

Reactant 2

HCID 321766-Methoxy-2-naphthylacetic acidHCID 65578Oxalyl chloride

Product 1

HCID 10988208HCID 10988208, compound

Procedure

To a solution dissolved 21.3 g (0.1 mol) of (6-methoxy-2-naphthyl)acetic acid in tetrahydrofuran anhydride (200 ml) was slowly added 19.0 g (0.15 mol) of oxalyl chloride and 1 ml of dimethylformamic at 0° C. After stirring at the room temperature for 15 hours, solvent and an excess of oxalyl chloride were removed to nearly quantitatively yield (6-methoxy-2-naphthyl)-acetyl chloride as product.

Workup

  1. customdimethylformamic at 0° C
  2. customsolvent and an excess of oxalyl chloride were removed to nearly quantitatively yield (6-methoxy-2-naphthyl)-acetyl chloride as product

Sources & evidence

ORD record
ord-7986c165c8b5486a9461eb1983c2ab21
Source dataset
uspto-grants-1992_09
Patent number
US05145993

Reaction notes

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