反应详情

A five neck five liter round bottom flask equipped with a mechanical stirrer, two condensers, and a dropping funnel was purged with nitrogen then charged under a nitrogen blanket with 1.25 kg (11.36 moles) hydroquinone, 350 grams deionized water, and 231.25 grams (1.07 moles) 1,4-dibromobutane. The reaction mass becomes a stirable slurry as it was slowly heated to reflux under a slow nitrogen purge. A solution of 180 grams (2.7 moles) 85 percent KOH pellets in 180 grams water was added dropwise under a nitrogen blanket over a two hour period. After about one third of the KOH had been added, the slurry had converted to a tea colored solution; then, after most of the KOH had been added, a white material precipitates in increasing amounts as the refluxing was continued an additional hour. The reaction mixture was quenched before cooling by pouring into 6 liters deionized water. The water slurry was acidified with 30 percent sulfuric acid and allowed to stand at room temperature overnight before filtering under reduced pressure and washing with several portions of boiling water to remove hydroquinone. The white residue was dried in a vacuum oven at 140° C. to a weight of 240 grams. It was then taken up in 4 liters boiling MEK, treated with decoloring carbon and filtered through a filter aid, celite, to remove particulates and colored impurities. A total of 154 grams of a white product was recovered from a series of filtrates. Analysis by gpc showed contamination by higher molecular weight species which were much less soluble in acetone than the desired product; thus, the product was taken up in boiling acetone, filtered, and cooled to recover 135 grams (46 percent yield based on the dibromobutane). HPLC analysis showed >90 percent purity by peak area. Another crystallization from 3 liters boiling acetone yields 116 grams of white "mica-like" crystals (melting point 202° C.-204° C.) with greater than 96 percent purity by HPLC peak area for use in examples 11 and 22. Both 1H and 13C NMR spectra were consistent with the proposed structure.

1. customA five neck five liter round bottom flask equipped with a mechanical stirrer
2. customtwo condensers, and a dropping funnel was purged with nitrogen
3. temperaturewas slowly heated
4. temperatureto reflux under a slow nitrogen
5. custompurge
6. customa white material precipitates
7. temperaturein increasing amounts as the refluxing
8. waitwas continued an additional hour
9. customThe reaction mixture was quenched
10. temperaturebefore cooling
11. additionby pouring into 6 liters
12. filtrationbefore filtering under reduced pressure
13. washwashing with several portions of boiling water
14. customto remove hydroquinone
15. customThe white residue was dried in a vacuum oven at 140° C. to a weight of 240 grams
16. additiontreated with decoloring carbon
17. filtrationfiltered through a filter aid, celite
18. customto remove particulates and colored impurities
19. customA total of 154 grams of a white product was recovered from a series of filtrates
20. filtrationfiltered
21. temperaturecooled
22. customto recover 135 grams (46 percent yield
23. customAnother crystallization from 3 liters