Potassium Carbonate → 2-[3-Phenyl-2-(methylsulfonylaminocarbonyl)phenoxy]-4,6-dimethoxypyrimidine

HRID 1885988Notes

Reaction equation

HRID 1885988 reaction equation
[C:1]1([C:7]2[C:12]([C:13]([O:15]C3C=CC([N+]([O-])=O)=CC=3)=O)=[C:11]([O:25][C:26]3[N:31]=[C:30]([O:32][CH3:33])[CH:29]=[C:28]([O:34][CH3:35])[N:27]=3)[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:36][S:37]([NH2:40])(=[O:39])=[O:38].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:1]1([C:7]2[C:12]([C:13]([NH:40][S:37]([CH3:36])(=[O:39])=[O:38])=[O:15])=[C:11]([CH:10]=[CH:9][CH:8]=2)[O:25][C:26]2[N:27]=[C:28]([O:34][CH3:35])[CH:29]=[C:30]([O:32][CH3:33])[N:31]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 72879MethanesulfonamideHCID 198765944-Nitrophenyl 6-phenyl-2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate

Product 1

HCID 198765872-[3-Phenyl-2-(methylsulfonylaminocarbonyl)phenoxy]-4,6-dimethoxypyrimidine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound is prepared in a manner analogous to that of Example 1, Step I, using equimolar amounts of 4-nitrophenyl 6-phenyl-2-(4,6-dimethoxypyrimidin-2-yloxy)benzoate, methanesulfonamide, and potassium carbonate in acetonitrile to yield 2-[3-phenyl-2-(methylsulfonylaminocarbonyl)phenoxy]-4,6-dimethoxypyrimidine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Example 1, Step I

Sources & evidence

ORD record
ord-f5f845e626324c3494abe95225dfa449
Source dataset
uspto-grants-1992_09
Patent number
US05149357

Reaction notes

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