HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → Almokalant
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 4-[3-[ethyl[3-(propylsulfinyl)-propyl]amino]-2-hydroxypropoxy]benzonitrile.HCl | HCID 131717529 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | Almokalant | HCID 3033962 | — |
Reaction Steps
To a stirred solution of 4-[3-[ethyl[3-(propylsulfinyl)-propyl]amino]-2-hydroxypropoxy]benzonitrile·HCl (5.5 g) in ethanol:water (1:1) (30 ml) was added sodium polystyrenesulfonate (5 g) at room temperature. After 30 minutes the resin was filtered and washed with ethanol:water (1:1) three times, and dried under high vacuum to constant weight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05149523 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-b380dd0e5b0242849106f579e91844d0 |
| Source note | uspto-grants-1992_09 |