Sodium → Almokalant

HRID 1885999Notes

Reaction equation

HRID 1885999 reaction equation
[CH2:1]([N:3]([CH2:17][CH2:18][CH2:19][S:20]([CH2:22][CH2:23][CH3:24])=[O:21])[CH2:4][CH:5]([OH:16])[CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1)[CH3:2].Cl.[Na]>C(O)C.O>[CH2:1]([N:3]([CH2:17][CH2:18][CH2:19][S:20]([CH2:22][CH2:23][CH3:24])=[O:21])[CH2:4][CH:5]([OH:16])[CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1)[CH3:2]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 1317175294-[3-[ethyl[3-(propylsulfinyl)-propyl]amino]-2-hydroxypropoxy]benzonitrile.HCl

Product 1

HCID 3033962Almokalant

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

To a stirred solution of 4-[3-[ethyl[3-(propylsulfinyl)-propyl]amino]-2-hydroxypropoxy]benzonitrile·HCl (5.5 g) in ethanol:water (1:1) (30 ml) was added sodium polystyrenesulfonate (5 g) at room temperature. After 30 minutes the resin was filtered and washed with ethanol:water (1:1) three times, and dried under high vacuum to constant weight.

Workup

  1. filtrationAfter 30 minutes the resin was filtered
  2. washwashed with ethanol:water (1:1) three times
  3. customdried under high vacuum to constant weight

Sources & evidence

ORD record
ord-b380dd0e5b0242849106f579e91844d0
Source dataset
uspto-grants-1992_09
Patent number
US05149523

Reaction notes

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