Thyroxine → Methyl thyroxinate hydrochloride

Participants

Reaction Steps

Thyroxine (1 g) was dissolved in the methanol/HCl, to which molecular sieve was added, and the mixture was left at room temperature overnight. The ester precipitates out with a yield of above 90%. After filtration, the product was washed with acetone and stored in a vacuum desiccator until use.

Provenance & Evidence