Hydrochloric Acid → HCID 19876822, compound

HRID 1886038Notes

Reaction equation

HRID 1886038 reaction equation
[N:1]1([NH:7][CH2:8][CH2:9][NH:10]C(=O)C)[CH:6]=[CH:5][CH:4]=[N:3][CH2:2]1.[OH-].[Na+].Cl>>[N:1]1([NH:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[N:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19876821HCID 19876821, compound

Product 1

HCID 19876822HCID 19876822, compoundYield 87%

Procedure

A solution of N-[2-[(pyrimidin-1-yl)amino]ethyl]acetamide (7.1 g, 0.039 mol) in 2.5N NaOH (47 mL, 0.118 mol) was heated under reflux for 22 hours. The mixture was cooled and the pH was adjusted to 8 with 2N HCl (38 mL). The mixture was concentrated, suspended in EtOH (100 mL) and filtered. The filtrate was concentrated to give an oily solid 4.7 g (87%).

Workup

  1. temperatureunder reflux for 22 hours
  2. temperatureThe mixture was cooled
  3. concentrationThe mixture was concentrated
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-42d32373d9e74a1498acaeca484cdc76
Source dataset
uspto-grants-1992_09
Patent number
US05149700

Reaction notes

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