Hydrochloric Acid → HCID 178432663, 화합물
반응식
[CH3:1][C:2]1[N:3]=[C:4]([CH3:28])[C:5]2[CH:11]=[CH:10][C:9](=[O:12])[N:8]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]#[N:27])=[CH:16][CH:15]=3)[C:6]=2[N:7]=1.[N-:29]=[N+:30]=[N-:31].[Na+].C([Sn](Cl)(CCCC)CCCC)CCC.Cl>>[CH3:1][C:2]1[N:3]=[C:4]([CH3:28])[C:5]2[CH:11]=[CH:10][C:9](=[O:12])[N:8]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:31][N:30]=[N:29][N:27]=4)=[CH:16][CH:15]=3)[C:6]=2[N:7]=1참가 물질
5
실험 절차
Using the same procedure as described in Step 3 of Example 8, heat a mixture of 2,4-dimethyl-8-[[2'-cyano[1,1-biphenyl]-4-yl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one, NaN3, and tri-n-butyltin chloride in xylenes under reflux for 48 h. Cool the mixture and add 1N HCl (2 mL). Add CHCl3 and water, and dry (MgSO4) and concentrate the organic phase. Recrystallization from EtOAc gives the product.