Chloroform → HCID 57324802, compound

HRID 1886109Notes

Reaction equation

HRID 1886109 reaction equation
[O:1]1[C@@H:5]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=2)[C@@H:2]1[CH2:3][OH:4].C(Cl)Cl.C(Cl)(Cl)Cl>CCCCCC.C(OCC)(=O)C>[O:1]1[C@@H:5]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:7]=2)[C@@H:2]1[CH:3]=[O:4]

Participants

5

Reactant 3

HCID 6212Chloroform2×HCID 6344DichloromethaneHCID 22840453HCID 22840453, compound

Product 1

HCID 57324802HCID 57324802, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound is prepared analogously to Example 5a) from (2S,3S)-2,3-epoxy-3-(3-trifluoromethylphenyl)-propanol. Light-yellow liquid; IR (CH2Cl2): 2820, 1730, 1330, 1165, 1130, 1070 cm-1 ; [α]D20 (chloroform, 0.20%)=0.0°±5°; [α]36520 (chloroform, 0.20%)=475.0°±5.0°; Rf =0.44 (hexane/ethyl acetate 7:3).

Sources & evidence

ORD record
ord-6f0ce3a084b54305acd3761c1d3fc276
Source dataset
uspto-grants-1992_09
Patent number
US05149717

Reaction notes

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