Glyoxal → HCID 15099949, compound

HRID 1886231Notes

Reaction equation

HRID 1886231 reaction equation
[CH2:1]([PH2:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH:8]([CH:10]=[O:11])=[O:9]>C(O)(C)C>[CH2:1]([P:7]1[CH:8]([OH:9])[CH:10]([OH:11])[P:7]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH:8]([OH:9])[CH:10]1[OH:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 7860GlyoxalHCID 151767HCID 151767, compound

Product 1

HCID 15099949HCID 15099949, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
60 °C

Procedure

In a suitable autoclave equipped as in Example 1, are added 200 parts of mono-n-hexylphosphine (93% purity) and 500 parts of isopropanol, as solvent. The mixture is heated to 60° C. and 240 parts of a 40% aqueous glyoxal solution are added. The reaction is allowed to proceed for one-hour and the solid product formed is filtered and dried to give 272 parts (98% yield) of 1,4-di-n-hexyl-2,3,5,6-tetrahydroxy-1,4-diphosphorinane, m.p. 140°-147° C.

Workup

  1. customIn a suitable autoclave equipped as in Example 1
  2. waitto proceed for one-hour
  3. customthe solid product formed
  4. filtrationis filtered
  5. customdried

Sources & evidence

ORD record
ord-a779e5ec952e4ef38a8cd269d7fa7313
Source dataset
uspto-grants-1992_09
Patent number
US05149878

Reaction notes

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