2',4'-Dihydroxyacetophenone → HCID 135708777, compound

HRID 1886317Notes

Reaction equation

HRID 1886317 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH3:10].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH2:20][CH2:21][C:22](=[O:25])[NH:23][N:24]=2)=[CH:15][CH:14]=1>>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[N:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH2:20][CH2:21][C:22](=[O:25])[NH:23][N:24]=2)=[CH:15][CH:14]=1)[CH3:10]

Participants

3

Reactant 2

HCID 69902',4'-DihydroxyacetophenoneHCID 6767506-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 135708777HCID 135708777, compound

Conditions

Temperature
140 °C

Procedure

A mixture containing 0.91 g (0.006 mol) of 2',4'-dihydroxyacetophenone and 0.95 g (0.005 mol) of 6-(4-aminophenyl)-4,5-dihydropyridazin-3(2H)one was heated for 4 h at 140° C. in a stream of nitrogen gas. The product was triturated with boiling ethanol and filtered. Yield 0.88 g (54%), m.p. 350° C. (decomp).

Workup

  1. customThe product was triturated with boiling ethanol
  2. filtrationfiltered

Sources & evidence

ORD record
ord-61c1948d6623469aa5288dec273879e6
Source dataset
uspto-grants-1992_09
Patent number
US05151420

Reaction notes

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