2',4'-Dihydroxypropiophenone → HCID 136113993, compound

HRID 1886318Notes

Reaction equation

HRID 1886318 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10]C.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]([CH3:27])[CH2:22][C:23](=[O:26])[NH:24][N:25]=2)=[CH:16][CH:15]=1>>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[N:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]([CH3:27])[CH2:22][C:23](=[O:26])[NH:24][N:25]=2)=[CH:16][CH:15]=1)[CH3:10]

Participants

3

Reactant 2

HCID 798562',4'-DihydroxypropiophenoneHCID 161928Ici 109,081

Product 1

HCID 136113993HCID 136113993, compound

Conditions

Temperature
140 °C

Procedure

A mixture of 0.167 g (0.0011 mol) of 2',4'-dihydroxypropiophenone and 0.203 g (0,001 mol) of 6-(4-aminophenyl)-4,5-dihydro-5-methylpyridazin-3(2H)one was heated for 1 h at 140° C. The product was triturated with ethanol and filtered. Yield 0.15 g (45%), m.p. 185°-190° C.

Workup

  1. customThe product was triturated with ethanol
  2. filtrationfiltered

Sources & evidence

ORD record
ord-d828bd7c8d854f1298c0e6a8a609d23c
Source dataset
uspto-grants-1992_09
Patent number
US05151420

Reaction notes

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