Hydrochloric Acid → HCID 22846043, compound

HRID 1886330Notes

Reaction equation

HRID 1886330 reaction equation
C([O:3][C:4]([C@@H:6]([NH:10][C@@H:11]([CH3:25])[C:12]([N:14]1[C@H:19]([C:20](=[O:22])[NH2:21])[CH:18]2[CH2:23][CH2:24][CH:15]1[CH2:16][CH2:17]2)=[O:13])[CH2:7][CH2:8][CH3:9])=[O:5])C.Cl>[OH-].[Na+]>[C:4]([C@@H:6]([NH:10][C@@H:11]([CH3:25])[C:12]([N:14]1[C@H:19]([C:20](=[O:22])[NH2:21])[CH:18]2[CH2:23][CH2:24][CH:15]1[CH2:16][CH2:17]2)=[O:13])[CH2:7][CH2:8][CH3:9])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53755056HCID 53755056, compound

Product 1

HCID 22846043HCID 22846043, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4.25 mmol (1.5 g) of the compound obtained in Example 1 are dissolved in 50 cm3 of 0.1N sodium hydroxide. The solution is left for 24 hours at room temperature, neutralized by adding 1N hydrochloric acid and then evaporated to dryness. The residue is taken up with 50 cm3 of isopropanol, filtered and evaporated, then taken up in 40 cm3 of water. The expected product is obtained after lyophilization.

Workup

  1. customevaporated to dryness
  2. filtrationfiltered
  3. customevaporated

Sources & evidence

ORD record
ord-7f85316665b64cf8b46d8d60ff7288dd
Source dataset
uspto-grants-1992_09
Patent number
US05151432

Reaction notes

Loading…