Methylamine → HCID 19875829, compound

HRID 1886348Notes

Reaction equation

HRID 1886348 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[CH:9]([CH3:11])[CH3:10])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].[CH3:16][NH2:17]>CO>[CH3:10][CH:9]([CH3:11])[C:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:17][CH3:16])=[C:3]([N+:13]([O-:15])=[O:14])[CH:4]=1)=[O:12]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 19875857HCID 19875857, compound

Product 1

HCID 19875829HCID 19875829, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
60 °C

Procedure

To a stirred solution of 30 parts of 1-(4-chloro-3-nitrophenyl)-2-methyl-1-propanone in 240 parts of methanol was added a solution of 20 parts of methanamine in 160 parts of methanol. After stirring for 12 hours at 60° C., the reaction mixture was evaporated to dry, yielding 30 parts (100%) of 2-methyl-1-[4-(methylamino)-3-nitrophenyl]-1-propanone as a residue (interm. 45).

Workup

  1. customthe reaction mixture was evaporated
  2. customto dry

Sources & evidence

ORD record
ord-4a23bcef97164770957a101669981e7d
Source dataset
uspto-grants-1992_09
Patent number
US05151421

Reaction notes

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