Potassium Iodide → HCID 2800353, compound

HRID 1886385Notes

Reaction equation

HRID 1886385 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][NH2:17].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>O.CN(C)C(=O)C>[N+:8]([C:7]1[C:2]([NH:17][CH2:16][C:12]2[S:11][CH:15]=[CH:14][CH:13]=2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 34005(2-Thienylmethyl)amineHCID 796132-Chloro-3-nitropyridine

Product 1

HCID 2800353HCID 2800353, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 180.0 parts of 2-chloro-3-nitropyridine, 122.0 parts of 2-thiophenemethanamine, 191.0 parts of sodium carbonate, 1 part of potassium iodide and 810 parts of N,N-dimethylacetamide was stirred for 1.50 hour at 100° C. The reaction mixture was poured into a lot of water (about 4000 parts). The whole was stirred overnight at room temperature. The precipitated product was filtered off and dried in vacuo at 40° C., yielding 251.5 parts of 3-nitro-N-(2-thienylmethyl)-2-pyridinamine; mp. 100° C. (interm. 1).

Workup

  1. stirringThe whole was stirred overnight at room temperature
  2. filtrationThe precipitated product was filtered off
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-c07181a5e9254b7a96a62022597dedf2
Source dataset
uspto-grants-1992_09
Patent number
US05151424

Reaction notes

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