反应详情

To a stirred and cooled (-10° C.) mixture of 63 parts of carbon disulfide, 52.1 parts of N,N'-methanetetraylbis[cyclohexanamine] and 360 parts of tetrahydrofuran were added dropwise 46.9 parts of ethyl 4-aminohexahydro-1H-azepine-1-carboxylate. Upon complete addition, the reaction mixture was stirred for 2 hours at room temperature. The reaction mixture was evaporated and the residue was stirred in 2,2'-oxybispropane. The precipitate was filtered off and the filtrate was evaporated, yielding 70.75 parts (100%) of ethyl hexahydro-4-isothiocyanato-1H-azepine-1-carboxylate as a residue (interm. 29).

1. temperaturecooled
2. additionUpon complete addition
3. stirringthe reaction mixture was stirred for 2 hours at room temperature
4. customThe reaction mixture was evaporated
5. stirringthe residue was stirred in 2,2'-oxybispropane
6. filtrationThe precipitate was filtered off
7. customthe filtrate was evaporated