Hydrochloric Acid → 4-Methyl-5-oxo-L-proline

HRID 1886494Notes

Reaction equation

HRID 1886494 reaction equation
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([CH3:11])[C:8](=[O:12])[NH:7]1)=[O:5])C.Cl>[OH-].[Na+]>[CH3:11][CH:9]1[C:8](=[O:12])[NH:7][C@H:6]([C:4]([OH:5])=[O:3])[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 4618797HCID 4618797, compound

Product 1

HCID 228093784-Methyl-5-oxo-L-proline

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The crystals (2.0 g) of 2-ethoxycarbonyl-4-methyl-5-oxopyrrolidine in the above-mentioned stage B were dissolved in a 2N sodium hydroxide solution (6 ml), and the solution was stirred at room temperature overnight. The mixture was neutralized with dilute hydrochloric acid, followed by concentration under reduced pressure. The residue was crystallized from water to give 4-methylpyroglutamic acid isomer A (900 mg) as crystals.

Workup

  1. concentrationfollowed by concentration under reduced pressure
  2. customThe residue was crystallized from water

Sources & evidence

ORD record
ord-bfe521ddd4b4407497d3a40b37cca4c6
Source dataset
uspto-grants-1992_09
Patent number
US05151497

Reaction notes

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