Trifluoroacetic acid → HCID 131717534, compound

HRID 1886502Notes

Reaction equation

HRID 1886502 reaction equation
C(OC([NH:8][C@@H:9]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH:10]([OH:22])[C:11]([F:21])([F:20])[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:14]1([CH2:13][CH2:12][C:11]([F:20])([F:21])[CH:10]([OH:22])[C@@H:9]([NH2:8])[CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131717535HCID 131717535, compound

Product 1

HCID 131717534HCID 131717534, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1 gm of the resultant product from Example 6 was added 5 ml of trifluoroacetic acid and 5 ml of dichloromethane. After one hour at room temperature, the solution was concentrated to an oil. The oil was dissolved in 100 ml EtOAc and washed with saturated NaHCO3 solution. The organic layer was dried with anhydrous Na2SO4 and evaporation of the solvent in vacuo provided a white solid, 740 mg (98%). Mass spectrum: (M+1)=306.

Workup

  1. concentrationthe solution was concentrated to an oil
  2. dissolutionThe oil was dissolved in 100 ml EtOAc
  3. washwashed with saturated NaHCO3 solution
  4. dry with materialThe organic layer was dried with anhydrous Na2SO4 and evaporation of the solvent in vacuo
  5. customprovided a white solid, 740 mg (98%)

Sources & evidence

ORD record
ord-46d1849bf8754ef0b486f4db5cd22102
Source dataset
uspto-grants-1992_09
Patent number
US05151438

Reaction notes

Loading…