1-(2-Chlorophenyl)-2-(1-tetrazolyl)ethanone → alpha-(2-Chlorophenyl)-2H-tetrazole-2-ethanol, (alphaR)-

HRID 1886770노트

반응식

HRID 1886770 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][N:10]1[N:14]=[N:13][CH:12]=[N:11]1.ClC1C=CC=CC=1C(=O)CN1C=NN=N1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:8]([OH:15])[CH2:9][N:10]1[N:14]=[N:13][CH:12]=[N:11]1

참가 물질

3

반응물 2

HCID 529147391-(2-Chlorophenyl)-2-(1-tetrazolyl)ethanoneHCID 671200911-(2-Chlorophenyl)-2-(2H-tetrazol-2-yl)ethanone

생성물 1

HCID 67120090alpha-(2-Chlorophenyl)-2H-tetrazole-2-ethanol, (alphaR)-

실험 절차

The same procedure as in Preparation Example 3 was repeated, with the exception that 1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-one, prepared in Preparation Example 2, was used instead of 1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-1-yl)ethan-1-one, to afford (R)-1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-ol (hereinafter referred to as “2N alcohol”). The conversion rate and optical purity of the product are given in Table 1, below.

후처리

  1. customThe same procedure as in Preparation Example 3
  2. customprepared in Preparation Example 2

출처 및 근거

ORD 기록
ord-1ebcb65b71f84c4b8ee1ed306232cb28
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501436B2

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