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1-(2-Chlorophenyl)-2-(1-tetrazolyl)ethanone → alpha-(2-Chlorophenyl)-2H-tetrazole-2-ethanol, (alphaR)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Chlorophenyl)-2-(1-tetrazolyl)ethanone | HCID 52914739 | — |
| 反応物 | 1-(2-Chlorophenyl)-2-(2H-tetrazol-2-yl)ethanone | HCID 67120091 | — |
| 生成物 | alpha-(2-Chlorophenyl)-2H-tetrazole-2-ethanol, (alphaR)- | HCID 67120090 | — |
反応手順
The same procedure as in Preparation Example 3 was repeated, with the exception that 1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-one, prepared in Preparation Example 2, was used instead of 1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-1-yl)ethan-1-one, to afford (R)-1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-ol (hereinafter referred to as “2N alcohol”). The conversion rate and optical purity of the product are given in Table 1, below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08501436B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-1ebcb65b71f84c4b8ee1ed306232cb28 |
| 出典メモ | uspto-grants-2013_08 |