HCID 68672834, compound → 4-(1,1-Dimethylethyl) hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-aspartate

HRID 1886837Notes

Reaction equation

HRID 1886837 reaction equation
[C:1]([NH:8][C@:9](N1C(=O)CCC1=O)([C:18]([OH:20])=[O:19])[CH:10](C(C)(C)C)[C:11]([OH:13])=[O:12])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CN(C=O)C>[NH:8]([C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])[C@H:9]([C:18]([OH:20])=[O:19])[CH2:10][C:11](=[O:12])[O:13][C:4]([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 1

HCID 68672834HCID 68672834, compound

Product 1

HCID 70106364-(1,1-Dimethylethyl) hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-aspartate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

FIG. 12 illustrates the synthesis of Mass Tag (3). To a mixture of N-Boc-β-tert-butyl-α-succinimido-aspartic acid (Boc-Asp(But)-OSu) (Bacchem, 0.1 mmol) in DMF (1 ml) was added hexamethyleneimine (Aldrich, 0.4 mmol). More DMF (2 ml) was added. The mixture was shaken at room temperature for 2 hours to form Boc-Asp(But)-HMI. Boc-Asp(But)-HMI was purified with preparative HPLC, and characterized with MS ([M+H]+: 371.3, calculated; 371.1, found).

Sources & evidence

ORD record
ord-9ed3689702c641039eeb39c8e3bcaf8b
Source dataset
uspto-grants-2013_08
Patent number
US08501498B2

Reaction notes

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