反应详情

温度

150 °C

To a solution of cyclohexanone (1.50 ml, 14.47 mmol) in toluene (24.12 ml) was added ethyl cyanoacetate (1.556 ml, 14.62 mmol), acetic acid (0.166 ml, 2.89 mmol), and ammonium acetate (0.112 g, 1.447 mmol). The mixture was heated to a reflux at 150° C. in a Dean-Stark apparatus. After 5 h, the reaction was cooled and washed with water and saturated NaHCO3 solution. The organics were dried over Na2SO4, filtered, and concentrated.

1. temperatureThe mixture was heated to
2. temperaturethe reaction was cooled
3. washwashed with water and saturated NaHCO3 solution
4. dry with materialThe organics were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated