反应详情

Concentrated H2SO4 (4.59 ml) was added dropwise to ethyl 2-(1-benzylcyclohexyl)-2-cyanoacetate (2.46 g, 8.62 mmol) at 0° C. The mixture was stirred at room temperature for 7 h. Ice water was added to the mixture resulting in a precipitate. The precipitate was taken up in Et2O and washed with 28% NH3 solution. The organics were washed with water, dried over Na2SO4, filtered, and concentrated to an orange oil.

1. customresulting in a precipitate
2. washwashed with 28% NH3 solution
3. washThe organics were washed with water
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated to an orange oil