Sulfuric Acid → ethyl 1-aminospiro[4H-naphthalene-3,1'-cyclohexane]-2-carboxylate

Participants

Reaction Steps

Concentrated H2SO4 (4.59 ml) was added dropwise to ethyl 2-(1-benzylcyclohexyl)-2-cyanoacetate (2.46 g, 8.62 mmol) at 0° C. The mixture was stirred at room temperature for 7 h. Ice water was added to the mixture resulting in a precipitate. The precipitate was taken up in Et2O and washed with 28% NH3 solution. The organics were washed with water, dried over Na2SO4, filtered, and concentrated to an orange oil.

Provenance & Evidence