反应详情

温度

125 °C

2-Fluoro-5-nitroaniline (1 g, 6.41 mmol), sodium sulfide nonahydrate (1.7 g, 7.05 mmol), sodium bicarbonate (600 mg, 7.05 mmol) and water (15 mL) were combined and heated in the microwave at 125° C. for 5 min. After cooling, dichloromethane was added, and the organic layer was washed with 2M aqueous hydrochloric acid and then brine. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 1.1 g (33%) of the title compound.

1. temperatureAfter cooling
2. washthe organic layer was washed with 2M aqueous hydrochloric acid
3. dry with materialThe combined organic layers were dried over anhydrous MgSO4
4. customevaporated