反应详情

7.9 mL (19.18 g, 120 mmol) of bromine were added dropwise to a suspension of 17.42 g (120 mmol) of compound 7 in 250 mL of chloroform at room temperature. After stirring for 2 h ethyl acetate was added. The precipitate was filtered, washed with ethyl acetate and dried. Aqueous NaHCO3 solution was added carefully. The precipitate was filtered and washed with NaHCO3 solution until the filtrate had a pH of 8. Drying gave 23.78 g (88%) of compound 9 as an off-white solid.

1. additionwas added
2. filtrationThe precipitate was filtered
3. washwashed with ethyl acetate
4. customdried
5. additionAqueous NaHCO3 solution was added carefully
6. filtrationThe precipitate was filtered
7. washwashed with NaHCO3 solution until the filtrate
8. customDrying