Hydrochloric Acid → HCID 57646935, compound

HRID 1887093Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([O:15][C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[CH:22]=[N:21][CH:20]=[CH:19]4)[CH2:11][CH2:10]2)=[CH:4][C:3]=1[S:26]([N:29]=CN(C)C)(=[O:28])=[O:27].[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:10][CH2:11][CH:12]([O:15][C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[CH:22]=[N:21][CH:20]=[CH:19]4)[CH2:13][CH2:14]2)=[CH:4][C:3]=1[S:26]([NH2:29])(=[O:28])=[O:27]

Participants

Conditions

Temperature: 60 °C

Procedure

133 mg (0.27 mmol) of 2-Chloro-N-dimethylaminomethylene-5-[4-(isoquinolin-6-yloxy)-piperidin-1-ylmethyl]-benzenesulfonamide (169) were dissolved in ethanol. After adding 50 ml of 2N NaOH, the solution was heated to 60° C. for 6 h. After cooling to room temperature, the mixture was neutralized by addition of aqueous HCl and the solvent was removed i. vac. The residue was stirred with ethanol, the inorganic salts were filtered off and the filtrate was evaporated. Rt=0.78 min (Method #2), Detected mass: 432.1 (M+H+).

Workup

temperatureAfter cooling to room temperature
customthe solvent was removed i
filtrationthe inorganic salts were filtered off
customthe filtrate was evaporated

Sources & evidence

ORD record: ord-9c814968a98d4a2dac3181455f6f1cc7
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501736B2

Reaction notes

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