7-Chloro-6-fluoroisoquinoline → 7-Chloro-6-(piperidin-4-yloxy)-isoquinoline-hydrochloride

HRID 1887095Notes

Reaction equation

HRID 1887095 reaction equation
[Cl:1]C1C=C2C(C=CN=C2)=CC=1F.[ClH:13].[NH:14]1[CH2:19][CH2:18][CH:17]([O:20][C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[CH:27]=[N:26][CH:25]=[CH:24]3)[CH2:16][CH2:15]1>>[ClH:1].[Cl:13][C:30]1[CH:29]=[C:28]2[C:23]([CH:24]=[CH:25][N:26]=[CH:27]2)=[CH:22][C:21]=1[O:20][CH:17]1[CH2:18][CH2:19][NH:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 534189227-Chloro-6-fluoroisoquinolineHCID 674289666-(Piperidin-4-yloxy)-isoquinoline hydrochloride

Product 1

HCID 674325377-Chloro-6-(piperidin-4-yloxy)-isoquinoline-hydrochloride

Procedure

Starting from 7-Chloro-6-fluoro-isoquinoline (150), the title compound was prepared by the same synthetic route as for compound 124. Rt=0.66 min (Method #1), detected mass: 263.1/265.1 (M+H+).

Sources & evidence

ORD record
ord-b7873a3d63494558a14efc1a9476d70c
Source dataset
uspto-grants-2013_08
Patent number
US08501736B2

Reaction notes

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