HCID 57646762, compound → HCID 15604837, compound

HRID 1887098Notes

Reaction equation

HRID 1887098 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:16]([C:38]3[CH:43]=[CH:42][C:41]([F:44])=[CH:40][CH:39]=3)=[C:17]3[C:22](=[CH:23][CH:24]=2)[CH:21]=[N:20][C:19]([NH:25][C:26]2[CH:31]=[C:30]([O:32][CH3:33])[C:29]([O:34][CH3:35])=[C:28]([O:36][CH3:37])[CH:27]=2)=[CH:18]3)[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)C.Cl>[F:44][C:41]1[CH:42]=[CH:43][C:38]([C:16]2[C:15]([O:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[C:19]([NH:25][C:26]2[CH:27]=[C:28]([O:36][CH3:37])[C:29]([O:34][CH3:35])=[C:30]([O:32][CH3:33])[CH:31]=2)[N:20]=[CH:21]3)=[CH:39][CH:40]=1

Participants

4

Reactant 1

HCID 57646762HCID 57646762, compound

Product 1

HCID 15604837HCID 15604837, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

20 mg of 4-[5-(4-Fluoro-phenyl)-3-(3,4,5-trimethoxy-phenylamino)-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (183) were dissolved in 5 ml of ethanol saturated with HCl (gaseous). The resulting mixture was stirred for 1 h, then the solvent was evaporated and the product collected. Yield: 85%

Workup

  1. customthe solvent was evaporated
  2. customthe product collected

Sources & evidence

ORD record
ord-9c9e54d993524c60bf8d48b2fefc66fd
Source dataset
uspto-grants-2013_08
Patent number
US08501736B2

Reaction notes

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