4-Aminophenylboronic acid → HCID 58006551, compound

HRID 1887157Notes

Reaction equation

HRID 1887157 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([CH:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1.B1(C2C=CC(N)=CC=2)OC(C)(C)C(C)(C)O1>>[CH:15]([N:11]1[CH2:12][CH2:13][CH2:14][N:8]([C:5]2[N:6]=[N:7][C:2]([C:22]3[CH:23]=[CH:24][C:19]([NH2:18])=[CH:20][CH:21]=3)=[CH:3][CH:4]=2)[CH2:9][CH2:10]1)([CH3:17])[CH3:16]

Participants

4

Reactant 3

HCID 27346154-Aminophenylboronic acidHCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 866371031-(6-Chloro-pyridazin-3-yl)-4-isopropyl-perhydro-1,4-diazepine

Product 1

HCID 58006551HCID 58006551, compound

Procedure

The title compound was prepared by a similar procedure to that described in Example 68, starting from 1-(6-chloro-pyridazin-3-yl)-4-isopropyl-perhydro-1,4-diazepine and 4-aminophenylboronic acid, pinacol cyclic ester. 1H NMR (400 MHz, CDCl3) δ 7.82 (d, 2H), 7.53 (d, 1H), 6.76 (m, 3H), 3.86 (t, 2H), 3.77 (m, 4H), 2.93 (heptet, 1H), 2.81 (m, 2H), 2.58 (m, 2H), 1.95 (m, 2H), 1.00 (d, 6H).

Sources & evidence

ORD record
ord-9ee0771ec86a4e838f4e23c8ae58e9d6
Source dataset
uspto-grants-2013_08
Patent number
US08501739B2

Reaction notes

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