反应详情

温度

55 °C

To a solution of 100 mg of 3-amino-isonicotinic acid in pyridine (2.5 mL) is added 117 mg of 1,1′-carbonyldiimidazole and the mixture is stirred for 20 min at 55° C. Then the mixture is cooled to room temperature and 91 mg of glycine methylester hydrochloride is added and the resulting mixture is stirred for 30 min at 55° C. and 1 h at room temperature. Then the solvent is removed under vacuum and the residue is purified by flash chromatography on silica gel to give 100 mg (66%) of [(3-amino-pyridine-4-carbonyl)-amino]-acetic acid methyl ester.

1. temperatureThen the mixture is cooled to room temperature
2. stirringthe resulting mixture is stirred for 30 min at 55° C. and 1 h at room temperature
3. customThen the solvent is removed under vacuum
4. customthe residue is purified by flash chromatography on silica gel