HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 25159571, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| Reactant | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| Reactant | 2-Aminoquinazoline-4-carboxylic acid | HCID 19390575 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 25159571 | HCID 25159571 | — |
Reaction Steps
1.2 100 mg of 2-amino-4-carboxyquinazoline and 261.6 mg of ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate are suspended in 5 ml of acetonitrile, and 146.6 μl of triethylamine are added. 53.6 mg of methylammonium chloride are added, and the mixture is stirred at 80° (bath temperature) for 16 hours. The mixture is cooled, the solvent is removed, and the product is purified by means of RP flash chromatography (Isco Compamion®);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501754B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-18965621431a48179656f80e51c42759 |
| Source note | uspto-grants-2013_08 |