Triethylamine → HCID 25159571, compound

HRID 1887222Notes

Reaction equation

HRID 1887222 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([C:12]([OH:14])=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.C(O[CH:18]1C=CC2C(=CC=CC=2)[N:19]1C(OCC)=O)C.C(N(CC)CC)C.[Cl-].C[NH3+]>C(#N)C>[NH2:1][C:2]1[N:11]=[C:10]([C:12](=[O:14])[NH:19][CH3:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 11637Methanamine, hydrochloride (1:1)HCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 193905752-Aminoquinazoline-4-carboxylic acid

Product 1

HCID 25159571HCID 25159571, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.2 100 mg of 2-amino-4-carboxyquinazoline and 261.6 mg of ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate are suspended in 5 ml of acetonitrile, and 146.6 μl of triethylamine are added. 53.6 mg of methylammonium chloride are added, and the mixture is stirred at 80° (bath temperature) for 16 hours. The mixture is cooled, the solvent is removed, and the product is purified by means of RP flash chromatography (Isco Compamion®);

Workup

  1. temperatureThe mixture is cooled
  2. customthe solvent is removed
  3. customthe product is purified by means of RP flash chromatography (Isco Compamion®)

Sources & evidence

ORD record
ord-18965621431a48179656f80e51c42759
Source dataset
uspto-grants-2013_08
Patent number
US08501754B2

Reaction notes

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