N,N,N',N'-Tetramethylethylenediamine → HCID 59483440, compound

HRID 1887225Notes

Reaction equation

HRID 1887225 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([C:12](=[O:18])[N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](Br)[CH:8]=2)[N:3]=1.[C]=[O:21].[CH3:22][N:23]([CH3:29])[CH2:24][CH2:25]N(C)C.CNCC[CH2:34][CH3:35]>O1CCOCC1>[NH2:1][C:2]1[N:11]=[C:10]([C:12](=[O:18])[N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:22](=[O:21])[N:23]([CH2:24][CH2:25][CH2:34][CH3:35])[CH3:29])[CH:8]=2)[N:3]=1

Participants

6

Reactant 4

HCID 8037N,N,N',N'-TetramethylethylenediamineHCID 8068N-MethylbutylamineHCID 25159695HCID 25159695, compoundHCID 178418416HCID 178418416, compound

Product 1

HCID 59483440HCID 59483440, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The following are reacted at 30 bar and 130° in an autoclave: 100 mg of 2-amino-6-bromo-4-diethylcarbamoylquinazoline, 30 ml of 1,4-dioxane, 7 ml of carbon monoxide, 10 mg of (1,1′-bis(diphenylphosphino)-ferrocene)dichloropalladium(II), 50 mg of N,N,N′,N′-tetramethylethylene-diamine and 80 mg of N-methylbutylamine.

Workup

  1. customThe following are reacted at 30 bar and 130° in an autoclave

Sources & evidence

ORD record
ord-8ecb65c2a0d849afa020a2b823d19b78
Source dataset
uspto-grants-2013_08
Patent number
US08501754B2

Reaction notes

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