2-Amino-6-(3-hydroxyprop-1-ynyl)-4-(1,3-dihydroisoindol-2-yl-carbonyl)quinazoline → [2-Amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]propynal

Participants

Reaction Steps

860 mg of 2-amino-6-(3-hydroxyprop-1-ynyl)-4-(1,3-dihydroisoindol-2-yl-carbonyl)quinazoline are dissolved in 2 ml of tetrahydrofuran and, after addition of 1.736 g of manganese(IV) oxide, stirred at room temperature for 16 h. After addition of a further 434 mg of manganese(IV) oxide, the mixture is stirred for a further 12 h, filtered through kieselguhr, and the filtrate is evaporated to dryness. Drying in vacuo gives 402 mg of “A965”.

Provenance & Evidence