反应详情

860 mg of 2-amino-6-(3-hydroxyprop-1-ynyl)-4-(1,3-dihydroisoindol-2-yl-carbonyl)quinazoline are dissolved in 2 ml of tetrahydrofuran and, after addition of 1.736 g of manganese(IV) oxide, stirred at room temperature for 16 h. After addition of a further 434 mg of manganese(IV) oxide, the mixture is stirred for a further 12 h, filtered through kieselguhr, and the filtrate is evaporated to dryness. Drying in vacuo gives 402 mg of “A965”.

1. stirringthe mixture is stirred for a further 12 h
2. filtrationfiltered through kieselguhr
3. customthe filtrate is evaporated to dryness
4. customDrying in vacuo
5. customgives 402 mg of “A965”