反应详情

温度

70 °C

To 35 mL CH3CN was added (6-Methyl-pyridin-2-yl)-methanol (3.5 g, 28.4 mmol), followed by potassium carbonate (17.9 g, 129.6 mmol), and 2-Chloro-1-fluoro-4-nitrobenzene (6.48 g, 36.9 mmol). The suspension was stirred and heated at 70° C. for 30 h, after which time the bright yellow mixture was allowed to cool to rt. The contents were cooled to rt, filtered, and washed with CH2Cl2. The filtrate was concentrated in vacuo to a a light yellow solid which was triturated with Hex/EtOAc (5:1), yielding 2-[(2-chloro-4-nitrophenoxy)methyl]-6-methylpyridine (4.87 g, 61%) as a white solid.

1. temperatureto cool to rt
2. temperatureThe contents were cooled to rt
3. filtrationfiltered
4. washwashed with CH2Cl2
5. concentrationThe filtrate was concentrated in vacuo to a a light yellow solid which
6. customwas triturated with Hex/EtOAc (5:1)