反应详情

5-bromo-2-(2-chlorophenyl)-N-cyclohexylimidazo[1,2-a]pyridin-3-amine 42 (152 mg, 0.376 mmol) was added to sodium ethoxide [generated in situ by addition of sodium metal (17.32 mg) to absolute ethanol (10 ml)]. The mixture was heated under reflux for 8 h. Excess solvent was removed in vacuo and the resultant mixture was treated with water before been extracted into ethyl acetate, dried over magnesium sulphate and filtered. Excess solvent was removed under reduced pressure to give an oil that was purified by column chromatography, eluting with hexane:ethyl acetate.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 8 h
3. customExcess solvent was removed in vacuo
4. additionthe resultant mixture was treated with water
5. extractionbefore been extracted into ethyl acetate
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. customExcess solvent was removed under reduced pressure
9. customto give an oil that
10. customwas purified by column chromatography
11. washeluting with hexane