TFA dichloromethane water → HCID 86761991, compound

HRID 1887546Notes

Reaction equation

HRID 1887546 reaction equation
C[O:2][CH:3](OC)[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH2:23][C@@H:24]4[CH2:28][CH2:27][CH2:26][O:25]4)[CH:18]=3)[C:13]2=[O:29])=[CH:8][C:7]=1[O:30][CH3:31].C(O)(C(F)(F)F)=O.ClCCl.O>>[CH3:31][O:30][C:7]1[CH:8]=[C:9]([N:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH2:23][C@@H:24]4[CH2:28][CH2:27][CH2:26][O:25]4)[CH:18]=3)[C:13]2=[O:29])[CH:10]=[CH:11][C:6]=1[O:5][CH2:4][CH:3]=[O:2]

Participants

3

Reactant 2

HCID 18672661TFA dichloromethane waterHCID 66879633HCID 66879633, compound

Product 1

HCID 86761991HCID 86761991, compound

Procedure

A solution of 2-[4-(2,2-dimethoxyethoxy)-3-methoxyphenyl]-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one (94 mg) in 10:10:1 TFA/dichloromethane/water (2 mL) was stirred at room temperature for 2 h. The solvent was removed in vacuo. The product with the molecular weight of 409.44 (C23H23NO6) was obtained in this way; MS (ESI): 428 (M+water+H+).

Workup

  1. customThe solvent was removed in vacuo
  2. customThe product with the molecular weight of 409.44 (C23H23NO6) was obtained in this way

Sources & evidence

ORD record
ord-6ca124c64c464b9684ef73ef611f3776
Source dataset
uspto-grants-2013_08
Patent number
US08501771B2

Reaction notes

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