反应详情

温度

70 °C

A mixture of 6-hydroxyisochroman-1-one (332 mg), methanesulfonic acid (S)-1-(tetrahydrofuran-2-yl)methyl ester (284 mg), cesium carbonate (1.28 g) and DMF (8 mL) was heated at 70° C. for 7 hours. The cooled reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The crude product was purified by chromatography on silica gel. The product with the molecular weight of 248.28 (C14H16O4) was obtained in this way; MS (ESI): 249 (M+H+).

1. customThe cooled reaction mixture
2. customwas partitioned between water and ethyl acetate
3. customThe organic phase was dried
4. concentrationconcentrated
5. customThe crude product was purified by chromatography on silica gel
6. customThe product with the molecular weight of 248.28 (C14H16O4) was obtained in this way