HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Methoxy-4-morpholinoaniline | HCID 414960 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-3-amine | HCID 58155011 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | N2-(2-methoxy-4-morpholinophenyl)-N4-(pyridin-3-yl)-5-(trifluoromethyl)pyridine-2,4-diamine | HCID 25074397 | — |
Reaction Steps
Method C was applied to a mixture of N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-3-amine (48 mg, 0.17 mmol), 2-methoxy-4-morpholinoaniline (55 mg, 0.27 mmol), Pd2(dba)3 (22 mg, 0.024 mmol), xantphos (24 mg, 0.041 mmol) and cesium carbonate (121 mg, 0.37 mmol) in dioxane (3 ml). The bis-TFA salt of the title compound was obtained as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501763B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b55745045e5d45b4801d6375cc81ac72 |
| Source note | uspto-grants-2013_08 |