反应详情

温度

80 °C

N-(6-Bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (15 g) was suspended in ethanol (150 mL), and ammonium formate (28.8 g) and 10% Pd—C (water content: 53%) (1.5 g) were added thereto. The mixture was heated at 80° C. while being stirred for 30 minutes, and water (150 mL) and ethanol (150 mL) were added thereto, followed by filtration while being heated. The filtrate was concentrated under reduced pressure, and the formed precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and diisopropyl ether, followed by drying, whereby the title compound (8.5 g) was yielded.

1. filtrationfollowed by filtration
2. temperaturewhile being heated
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe formed precipitates
5. filtrationwere recovered through filtration
6. washThe thus-obtained solid was washed with ethanol and diisopropyl ether
7. customby drying