Hydrochloric Acid → HCID 68412119, compound

HRID 1887745Notes

Reaction equation

HRID 1887745 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH:8]([NH:13]C(=O)C)[CH2:7]2.[ClH:17]>>[ClH:17].[ClH:17].[NH2:13][CH:8]1[CH2:7][C:6]2[C:11](=[C:2]([NH2:1])[CH:3]=[CH:4][CH:5]=2)[NH:10][C:9]1=[O:12]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59620340HCID 59620340, compound

Product 1

HCID 68412119HCID 68412119, compound

Conditions

Temperature
110 °C

Procedure

N-(8-Amino-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (8.4 g) was added to concentrated hydrochloric acid (84 mL), and the mixture was heated at 110° C. for three hours while being stirred, followed by stirring under cooling on ice. The formed precipitates were recovered through filtration, and the thus-obtained solid was washed with ethanol, followed by drying, whereby the title compound (9.17 g) was yielded.

Workup

  1. stirringby stirring
  2. temperatureunder cooling on ice
  3. customThe formed precipitates
  4. filtrationwere recovered through filtration
  5. washthe thus-obtained solid was washed with ethanol
  6. customby drying

Sources & evidence

ORD record
ord-9e45c8415a57486b805f7f50f46222de
Source dataset
uspto-grants-2013_08
Patent number
US08501772B2

Reaction notes

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