Hydrochloric Acid → HCID 68413743, compound

HRID 1887777Notes

Reaction equation

HRID 1887777 reaction equation
[NH2:1][C:2]([CH3:39])([CH3:38])[C:3]([NH:5][C@H:6]([CH2:34][CH:35]([CH3:37])[CH3:36])[C:7]([NH:9][CH:10]1[CH2:19][C:18]2[C:13](=[C:14]([N:20]3[C:24](=[O:25])[CH2:23][CH2:22][C:21]3=[O:26])[CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:27][C:28]2[CH:32]=[CH:31][S:30][CH:29]=2)[C:11]1=[O:33])=[O:8])=[O:4].[ClH:40]>C(O)C>[ClH:40].[NH2:1][C:2]([CH3:38])([CH3:39])[C:3]([NH:5][C@H:6]([CH2:34][CH:35]([CH3:36])[CH3:37])[C:7]([NH:9][CH:10]1[CH2:19][C:18]2[C:13](=[C:14]([N:20]3[C:21](=[O:26])[CH2:22][CH2:23][C:24]3=[O:25])[CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:27][C:28]2[CH:32]=[CH:31][S:30][CH:29]=2)[C:11]1=[O:33])=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59620347HCID 59620347, compound

Product 1

HCID 68413743HCID 68413743, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(2R)-2-(2-Amino-2-methylpropanamido)-N-(8-(2,5-dioxopyrrolidin-1-yl)-2-oxo-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl)-4-methylpentanamide (14 mg) was dissolved in ethanol (1 mL), and concentrated hydrochloric acid (35% aqueous hydrochloric acid solution) (25 μL) was added thereto. The solvent was evaporated under reduced pressure, whereby the title compound (16 mg) was yielded.

Workup

  1. customThe solvent was evaporated under reduced pressure, whereby the title compound (16 mg)
  2. customwas yielded

Sources & evidence

ORD record
ord-416d1f5b49b0481fb89fa9a0c720fabf
Source dataset
uspto-grants-2013_08
Patent number
US08501772B2

Reaction notes

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