反应详情

In a 250 mL round-bottomed flask, 3-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one (intermediate D) (1 g, 3.51 mmol), 4-nitrophenyl chloroformate (708 mg, 3.51 mmol) and N,N-diisopropylethylamine (1.36 g, 1.84 mL, 10.5 mmol) were combined with CH2Cl2 (30 mL). The reaction mixture was stirred overnight at room temperature. After this time, the reaction mixture was concentrated to dryness to afford (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-carbamic acid 4-nitro-phenyl ester (1.6 g, 100%)

1. concentrationAfter this time, the reaction mixture was concentrated to dryness