Hydrochloric Acid → HCID 71208682, compound

Participants

Reaction Steps

In a 250 mL flask, tert-butyl 4-(3-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)ureido)piperidine-1-carboxylate (1.6 g, 3.13 mmol) and HCl gas were combined with dioxane (30 mL). The reaction mixture was stirred overnight at room temperature. After this time, LC/MS showed the reaction to be complete. The product 1-(7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-ylmethyl)-3-piperidin-4-yl-urea hydro-chloride salt (1.4 g, 100%) was used in subsequent steps without further purification.

Provenance & Evidence