Hydrochloric Acid → HCID 71208682, compound

HRID 1887830Notes

Reaction equation

HRID 1887830 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:36])[C:7]([CH2:18][NH:19][C:20](=[O:35])[NH:21][CH:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]3)=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:36])[C:7]([CH2:18][NH:19][C:20]([NH:21][CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[O:35])=[CH:8][N:9]2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71208227HCID 71208227, compound

Product 1

HCID 71208682HCID 71208682, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a 250 mL flask, tert-butyl 4-(3-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)ureido)piperidine-1-carboxylate (1.6 g, 3.13 mmol) and HCl gas were combined with dioxane (30 mL). The reaction mixture was stirred overnight at room temperature. After this time, LC/MS showed the reaction to be complete. The product 1-(7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-ylmethyl)-3-piperidin-4-yl-urea hydro-chloride salt (1.4 g, 100%) was used in subsequent steps without further purification.

Workup

  1. customthe reaction
  2. customThe product 1-(7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-ylmethyl)-3-piperidin-4-yl-urea hydro-chloride salt (1.4 g, 100%) was used in subsequent steps without further purification

Sources & evidence

ORD record
ord-a142c403fdeb46a9878b1019873481c0
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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