1-Methyl-1H-pyrazole-4-carboxylic acid → Methyl-1H-pyrazole-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)-amide

HRID 1887841Notes

Reaction equation

HRID 1887841 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4]=1[C:20]1[O:21][CH:22]=[CH:23][N:24]=1.[CH3:25][N:26]1[CH:30]=[C:29]([C:31](O)=[O:32])[CH:28]=[N:27]1>>[O:21]1[CH:22]=[CH:23][N:24]=[C:20]1[C:4]1[N:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:31]([C:29]1[CH:28]=[N:27][N:26]([CH3:25])[CH:30]=1)=[O:32])=[CH:10][CH:9]=[CH:8][N:7]=2

Participants

3

Reactant 2

HCID 6431601-Methyl-1H-pyrazole-4-carboxylic acidHCID 712085053-(aminomethyl)-2-(oxazol-2-yl)-1-phenyl-1,8-naphthyridin-4(1H)-one

Product 1

HCID 71217335Methyl-1H-pyrazole-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)-amide

Procedure

Methyl-1H-pyrazole-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)-amide was prepared starting from intermediate B and 1-methyl-1H-pyrazole-4-carboxylic acid. MS calcd. for C23H19N6O3 [(M+H)+] 427.1, obsd. 427.2.

Sources & evidence

ORD record
ord-4a596aa3687f4ee49381c129df1f9aef
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

Loading…